cis-5-Norbornene-exo-2,3-dicarboxylic anhydride lurasidone intermediate CAS NO.2746-19-2

Nanjing Legend Pharmaceutical & Chemical Co., Ltd is a research-based pharmaceutical & chemical enterprise dedicated to the development, manufacture and marketing of novel products in pharmaceuticals and fine chemicals . 
Legend has technological competencies in asymmetric synthesis, organomatelic chemistry, chiral chemistry and multi-step synthesis. Legend has formed competitive advantage globally in the supply of certain chiral APIs, Antivirus intermediates & chiral reagents and etc. Products and services are served to customers and partners in Asia, Europe, North America and South America. Legend vision is to become a global leader in the development and commercialization of certain innovative products in the fields of Anti-Viral intermediates，chiral chemicals, pharmaceuticals and to create value for  customers, employees, stakeholders and society to live a better life.

CMO of innovative pharmaceutical products--API & Intermediate

Advantages：
Excellent production conditions: The multi-function workshops can supply product from milligram to kilogram and to ton; specializes in ultra-low temperature ,high-pressure hydrogenation and other unconventional reaction;research results can be quickly converted into industrialization. 

Strict quality control system: product quality standards are established in accordance with the requirements of ICH guidance.Enquan is more concerned about the quality of products than the customer, for example, more attention are paid on impurity transfer and impurity profile study in the process development,esp.on drug intermediates impurity control. 

The CAS register number of 4,7-Methanoisobenzofuran-1,3-dione,3a,4,7,7a-tetrahydro-, (3aR,4R,7S,7aS)-rel- is 2746-19-2. It also can be called as cis-Norbornene-exo-2,3-dicarboxylic anhydride and the systematic name about this chemical is 3a,4,7,7a-tetrahydro-4,7-methano-2-benzofuran-1,3-dione. The molecular formula about this chemical is C₉H₈O₃ and the molecular weight is 164.16. It belongs to the following product categories which include Alicyclic/Etch-Resistant Monomers; Lithography Monomers; Self Assembly & Contact Printing and so on.

Physical properties about 4,7-Methanoisobenzofuran-1,3-dione,3a,4,7,7a-tetrahydro-, (3aR,4R,7S,7aS)-rel- are: (1) ACD/BCF (pH 5.5): 1; (2)ACD/BCF (pH 7.4): 1; (3)ACD/KOC (pH 5.5): 20.96; (4)ACD/KOC (pH 7.4): 20.96; (5)#H bond acceptors: 3; (6)Polar Surface Area: 43.37 Å²; (7)Index of Refraction: 1.584; (8)Molar Refractivity: 39.08 cm³; (9)Molar Volume: 116.78 cm³; (10)Polarizability: 15.493x10^-24cm³; (11)Surface Tension: 50.991 dyne/cm; (12)Density: 1.406 g/cm³; (13)Flash Point: 163.801 °C; (14)Enthalpy of Vaporization: 57.369 kJ/mol; (15)Boiling Point: 331.056 °C at 760 mmHg.

Preparation: this chemical can be prepared by norborn-5-ene-2endo,3endo-dicarboxylic acid anhydride. The reaction temperature is 190 °C. The yield is about 22%.

Uses of 4,7-Methanoisobenzofuran-1,3-dione,3a,4,7,7a-tetrahydro-, (3aR,4R,7S,7aS)-rel-: it can be used to produce norbornane-2exo,3exo-dicarboxylic acid-anhydride. This reaction will need reagents of platinum, ethyl acetate. This reaction needs hydrogenation.

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to respiratory system and skin. There is risk of serious damage to the eyes. So, if you want to use it, wear suitable protective clothing. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to store it, you should keep the container tightly sealed in dry, cool places. If you store and use this chemical according the rule, it will not be decomposed.

You can still convert the following datas into molecular structure:
(1)SMILES: C1C2C=CC1C3C2C(=O)OC3=O 
(2)InChI: InChI=1/C9H8O3/c10-8-6-4-1-2-5(3-4)7(6)9(11)12-8/h1-2,4-7H,3H2 
(3)InChIKey: KNDQHSIWLOJIGP-UHFFFAOYAJ
(4)Std. InChI: InChI=1S/C9H8O3/c10-8-6-4-1-2-5(3-4)7(6)9(11)12-8/h1-2,4-7H,3H2 
(5)Std. InChIKey: KNDQHSIWLOJIGP-UHFFFAOYSA-N